Three men were arrested for “racially aggravated public order offences” prior to Tottenham’s 1-0 win over Chelsea in the Carabao Cup semi-final first leg.
The men, aged 17, 20 and 23, were arrested 20 minutes before kick-off at Wembley, while a fourth man, aged 30, was arrested for drugs offences.
The Metropolitan Police said all four were taken to a north London police station on Tuesday evening.
Both clubs had warned supporters about their behaviour before the match.
The full nature of the offences is unknown, while it is also unknown whether the men arrested were Tottenham or Chelsea fans.
It comes just days after a Chelsea fan was fined £965 and banned from attending football matches for three years after being found guilty of homophobic chants.
Last month, Chelsea suspended four supporters from attending matches while an investigation into the alleged racial abuse of Manchester City forward Raheem Sterling takes place.
Also in December, Chelsea condemned a vocal minority of their fans for anti-Semitic chants during a Europa League match with MOL Vidi in Hungary.